Dissections or ruptures of aortic aneurysms remain a leading cause of death in the
developed world, with the majority of deaths being preventable if individuals at risk are …

Elastic fibers are major components of the extracellular matrix (ECM) in the aorta and
support a life-long cycling of stretch and recoil. Elastic fibers are formed from mid-gestation …

Importance Fluoroquinolones are among the most commonly prescribed antibiotics. Recent
clinical studies indicated an association between fluoroquinolone use and increased risk of …

Thoracic aortic aneurysm is a typically silent disease characterized by a lethal natural
history. Since the discovery of the familial nature of thoracic aortic aneurysm and dissection …

Copper is vital for numerous cellular functions affecting all tissues and organ systems in the
body. The copper pump, ATP7A is critical for whole-body, cellular, and subcellular copper …

Thoracic aortic aneurysms, with an estimated prevalence in the general population of 1%,
are potentially lethal, via rupture or dissection. Over the prior two decades, there has been …

Thoracic aortopathy, especially aneurysm, dissection, and rupture, is responsible for
significant morbidity and mortality. Uncontrolled hypertension and aging are primary risk …

Aortic aneurysm is a permanent focal dilation of the aorta. It is usually an asymptomatic
disease but can lead to sudden death due to aortic rupture. Aortic aneurysm-related …

In the arteries of vertebrates, evolution has given rise to resilient macromolecular structures,
elastin and elastic fibers, capable of sustaining an elevated blood pressure and …

Objective: Copper (Cu) is essential micronutrient, and its dysregulation is implicated in aortic
aneurysm (AA) development. The Cu exporter ATP7A (copper-transporting P-type …