Tumour burden and efficacy of immune-checkpoint inhibitors

FG Dall'Olio, A Marabelle, C Caramella… - Nature reviews Clinical …, 2022 - nature.com
Accumulating evidence suggests that a high tumour burden has a negative effect on
anticancer immunity. The concept of tumour burden, simply defined as the total amount of …

Risks from deferring treatment for genitourinary cancers: a collaborative review to aid triage and management during the COVID-19 pandemic

CJD Wallis, G Novara, L Marandino, A Bex, AM Kamat… - European urology, 2020 - Elsevier
Context The coronavirus disease 2019 (COVID-19) pandemic is leading to delays in the
treatment of many urologic cancers. Objective To provide a contemporary picture of the risks …

Kidney cancer, version 3.2022, NCCN clinical practice guidelines in oncology

RJ Motzer, E Jonasch, N Agarwal, A Alva… - Journal of the National …, 2022 - jnccn.org
The NCCN Guidelines for Kidney Cancer focus on the screening, diagnosis, staging,
treatment, and management of renal cell carcinoma (RCC). Patients with relapsed or stage …

Management of metastatic clear cell renal cell carcinoma: ASCO guideline

WK Rathmell, RB Rumble… - Journal of Clinical …, 2022 - ingentaconnect.com
PURPOSE To provide recommendations for the management of patients with metastatic
clear cell renal cell carcinoma (ccRCC). METHODS An Expert Panel conducted a systematic …

[HTML][HTML] Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial

CC Parker, ND James, CD Brawley, NW Clarke… - The Lancet, 2018 - thelancet.com
Background Based on previous findings, we hypothesised that radiotherapy to the prostate
would improve overall survival in men with metastatic prostate cancer, and that the benefit …

Comparison of immediate vs deferred cytoreductive nephrectomy in patients with synchronous metastatic renal cell carcinoma receiving sunitinib: the SURTIME …

A Bex, P Mulders, M Jewett, J Wagstaff… - JAMA …, 2019 - jamanetwork.com
Importance In clinical practice, patients with primary metastatic renal cell carcinoma (mRCC)
have been offered cytoreductive nephrectomy (CN) followed by targeted therapy, but the …

Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

B Escudier, C Porta, M Schmidinger… - Annals of …, 2019 - annalsofoncology.org
Kidney cancer accounts for 5% and 3% of all adult malignancies in men and women,
respectively, thus representing the 7th most common cancer in men, and the 10th most …

NCCN guidelines insights: kidney cancer, version 2.2020: featured updates to the NCCN guidelines

RJ Motzer, E Jonasch, MD Michaelson… - Journal of the National …, 2019 - jnccn.org
The NCCN Guidelines for Kidney Cancer provide multidisciplinary recommendations for the
clinical management of patients with clear cell and non–clear cell renal cell carcinoma, and …

Clinical review on the management of metastatic renal cell carcinoma

J Tran, MC Ornstein - JCO Oncology Practice, 2022 - ascopubs.org
Renal cell carcinomas vary considerably in their tumor biology and disease course, which is
reflected in the range of treatment paradigms in localized and metastatic renal cell …

Towards individualized therapy for metastatic renal cell carcinoma

RR Kotecha, RJ Motzer, MH Voss - Nature reviews Clinical oncology, 2019 - nature.com
Over the past decade, the treatment landscape for patients with metastatic renal cell
carcinoma (RCC) has evolved dramatically. The therapeutic options available have …