The endoplasmic reticulum (ER) uses an elaborate surveillance system called the ER
quality control (ERQC) system. The ERQC facilitates folding and modification of secretory …

The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …

The lysosome is a degradative organelle, and its fusion with other organelles is strictly
regulated. In contrast to fusion with the late endosome, the mechanisms underlying …

The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the
membrane of the human endoplasmic reticulum (ER) and play a central role in translocation …

Integral membrane proteins of the cell surface and most intracellular compartments of
eukaryotic cells are assembled at the endoplasmic reticulum. Two highly conserved and …

Membrane-bound organelles such as mitochondria, peroxisomes, or the endoplasmic
reticulum (ER) create distinct environments to promote specific cellular tasks such as ATP …

The ER (endoplasmic reticulum) is the protein folding 'factory'of the secretory pathway.
Virtually all proteins destined for the plasma membrane, the extracellular space or other …

Peroxisomes are unique among the organelles of the endomembrane system. Unlike other
organelles that derive most if not all of their proteins from the ER (endoplasmic reticulum) …

One-fourth of eukaryotic genes code for integral membrane proteins, nearly all of which are
inserted and assembled at the endoplasmic reticulum (ER). The defining feature of …

Abstract In mammalian cells,> 25% of synthesized proteins are exported through the
secretory pathway. The pathway complexity, however, obfuscates its impact on the secretion …