The initiation of T cell antigen receptor signaling is a key step that can result in T cell
activation and the orchestration of an adaptive immune response. Early events in T cell …

The non-receptor tyrosine kinase Csk serves as an indispensable negative regulator of the
Src family tyrosine kinases (SFKs) by specifically phosphorylating the negative regulatory …

Comorbidities of hidradenitis suppurativa (acne inversa) were reviewed by extracting
original and review publications included in MEDLINE, EMBASE and COCHRANE libraries …

Inheritance of a coding variant of the protein tyrosine phosphatase nonreceptor type 22
(PTPN22) gene is associated with increased susceptibility to autoimmunity and infection …

Lymphocyte activation must be tightly regulated to ensure sufficient immunity to pathogens
and prevent autoimmunity. Protein tyrosine phosphatases (PTPs) serve critical roles in this …

PAPA syndrome (Pyogenic Arthritis, Pyoderma gangrenosum, and Acne) is an autosomal
dominant, hereditary auto-inflammatory disease arising from mutations in the …

The ability of a protein to fold into unique functional state or to stay intrinsically disordered is
encoded in its amino acid sequence. Both ordered and intrinsically disordered proteins …

Abstract The IL-2/IL-2R signaling pathway has an important role in autoimmunity. Several
genes identified in genome-wide association (GWA) studies encode proteins in the IL-2/IL …

More than half of the known protein tyrosine phosphatases (PTPs) in the human genome are
expressed in T cells, and significant progress has been made in elucidating the biology of …

Chronic recurrent multifocal osteomyelitis (CRMO), also known as chronic nonbacterial
osteomyelitis, is an orphan disease that manifests as recurrent flares of inflammatory bone …