The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an
animal model of depression more than 20 years ago. The foundation of this model was that …

Psychiatric disorders are frequently encountered in many neurological disorders, such as
Alzheimer's and Parkinson diseases along with epilepsy, migraine, essential tremors, and …

The prevalence and comorbidity of psychiatric disorders such as depression, anxiety and
insomnia are very common. These well-known forms of psychiatric disorders have been …

Depression is a serious disorder that affects hundreds of millions of people around the world
and causes poor quality of life, problem behaviors, and limitations in activities of daily living …

Background Depression is one of the most debilitating and severe psychiatric disorders and
a serious public health concern. Currently, many treatments are indicated for depression …

Paeoniflorin, the main component of Xiaoyao Wan, presents low oral bioavailability and
unclear antidepressant mechanism. To elucidate the potential reasons for the low …

Depression is a mental and emotional disorder that has made an opening great burden to
the society. Paeoniflorin showed remarkable antidepressant-like effects in multiple animal …

Medicinal plants and their extracts are natural remedies with enormous potential for treating
various diseases, including depression and anxiety. In the case of depression, hundreds of …

Depression is a serious widespread psychiatric disorder that affects approximately 17% of
people all over the world. Exploring the neurological mechanisms of the antidepressant …

Neuronal damage is related to the onset and treatment of depressive disorders.
Antidepressant-like effects have been elicited by paeoniflorin on animal models. The aim of …