It was nearly 30 years before the V-type H+ ATPase was admitted to the small circle of bona
fide transport ATPases alongside F-type and P-type ATPases. The V-type H+ ATPase is an …

The exquisite sensitivity of the cochlea, which mediates the transduction of sound waves into
nerve impulses, depends on the endocochlear potential and requires a highly specialized …

H+-ATPases are ubiquitous in nature; V-ATPases pump protons against an electrochemical
gradient, whereas F-ATPases reverse the process, synthesizing ATP. We demonstrate here …

Tight junctions in the cochlear duct are thought to compartmentalize endolymph and provide
structural support for the auditory neuroepithelium. The claudin family of genes is known to …

Vacuolar H+-ATPases are ubiquitous multisubunit complexes mediating the ATP-dependent
transport of protons. In addition to their role in acidifying the lumen of various intracellular …

Autosomal recessive distal renal tubular acidosis (rdRTA) is characterised by severe
hyperchloraemic metabolic acidosis in childhood, hypokalaemia, decreased urinary calcium …

The kidneys have a central role in the control of acid–base homeostasis owing to
bicarbonate reabsorption and production of ammonia and ammonium in the proximal tubule …

Background: Otoconia are bio‐crystals that couple mechanic forces to the sensory hair cells
in the utricle and saccule, a process essential for us to sense linear acceleration and gravity …

Pendred's syndrome is an autosomal-recessive disorder characterized by deafness and
goiter. After our recent identification of the human gene mutated in Pendred's syndrome …

A primary function of the H+-ATPase (or V-ATPase) is to create an electrochemical proton
gradient across eukaryotic cell membranes, which energizes fundamental cellular …