The autonomic nervous system plays an important role in the modulation of cardiac
electrophysiology and arrhythmogenesis. Decades of research has contributed to a better …

There is mounting evidence to support the influence of inflammation in the pathogenesis of
atrial fibrillation (AF). Indeed, AF is associated with increased levels of known inflammatory …

ContextAtrial fibrillation (AF) is the most common cardiac dysrhythmia in the United States.
Whereas rare cases of familial AF have been reported, it is unknown if AF among unselected …

BACKGROUND: Atrial fibrillation (AF) and chronic kidney disease share risk factors and
pathophysiologic mechanisms, suggesting that two conditions have close relationships …

Objectives: This study was designed to evaluate whether different antihypertensive
treatment regimens with similar blood pressure reduction have different effects on new-onset …

Role of Inflammation in Initiation and Perpetuation of Atrial Fibrillation: A Systematic Review
of the Published Data Tim T. Issac, Hisham Dokainish, Nasser M. Lakkis Atrial fibrillation …

Detecting, characterizing, and interpreting gene–gene interactions or epistasis in studies of
human disease susceptibility is both a mathematical and a computational challenge. To …

Epistatic interactions among multiple genetic variants in the human genome may be
important in determining individual susceptibility to common diseases. Although some …

Multifactor dimensionality reduction (MDR) was developed as a method for detecting
statistical patterns of epistasis. The overall goal of MDR is to change the representation …

Atrial fibrillation (AF) is a common arrhythmia that is difficult to treat. Anti-arrhythmic drug
therapy, to maintain sinus-rhythm, is limited by inadequate efficacy and potentially serious …