Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

There is evidence that certain infections may induce obesity. Obese persons may also have
more severe infections and have compromised response to therapies. The objective of this …

METHODS: A total of 375 treatment-naive, H. pylori-infected subjects were randomly
assigned in a 1: 1: 1 ratio into 3 regimen groups including VHA-dual (vonoprazan 20 mg …

Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (% T) during which their free serum concentration …

The increased prevalence of obesity presents challenges for clinicians aiming to provide
optimised antimicrobial dosing in the intensive care unit. Obesity is likely to exacerbate the …

The treatment of infections in critically ill obese and morbidly obese patients is challenging
because of the combined physiological changes that result from obesity and critical illness …

Background As a first‐line therapy for Helicobacter pylori, dual therapy with vonoprazan and
amoxicillin (VA‐dual) provides an eradication rate similar to that of vonoprazan‐based triple …

Introduction: Identifying the optimized dosing regimen and algorithm is critical in the
development of antibiotics. Suboptimal regimens and inappropriate choice of drug give rise …

Abstract Purpose of Review Beta-lactam antibiotics are commonly prescribed in critically ill
patients for a variety of infectious conditions. Our understanding of how critical illness alters …

The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in …