Deep learning in drug discovery: an integrative review and future challenges

H Askr, E Elgeldawi, H Aboul Ella… - Artificial Intelligence …, 2023 - Springer
Recently, using artificial intelligence (AI) in drug discovery has received much attention
since it significantly shortens the time and cost of developing new drugs. Deep learning (DL) …

Digital twins in pharmaceutical and biopharmaceutical manufacturing: a literature review

Y Chen, O Yang, C Sampat, P Bhalode… - Processes, 2020 - mdpi.com
The development and application of emerging technologies of Industry 4.0 enable the
realization of digital twins (DT), which facilitates the transformation of the manufacturing …

Modernizing pharmaceutical manufacturing: from batch to continuous production

SL Lee, TF O'Connor, X Yang, CN Cruz… - Journal of …, 2015 - Springer
Abstract The Food and Drug Administration (FDA) regulates pharmaceutical drug products
to ensure a continuous supply of high-quality drugs in the USA. Continuous processing has …

[HTML][HTML] The future of pharmaceutical manufacturing sciences

J Rantanen, J Khinast - Journal of pharmaceutical sciences, 2015 - Elsevier
The entire pharmaceutical sector is in an urgent need of both innovative technological
solutions and fundamental scientific work, enabling the production of highly engineered …

End‐to‐end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation

S Mascia, PL Heider, H Zhang, R Lakerveld… - Angewandte …, 2013 - Wiley Online Library
For the past decade, the pharmaceutical industry has been under pressure to improve
efficiency, as rising costs outpaced the development of new pharmaceuticals.[1] A growing …

Assessment of recent process analytical technology (PAT) trends: a multiauthor review

LL Simon, H Pataki, G Marosi, F Meemken… - … Process Research & …, 2015 - ACS Publications
This multiauthor review article aims to bring readers up to date with some of the current
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …

Population balance modeling: current status and future prospects

D Ramkrishna, MR Singh - Annual review of chemical and …, 2014 - annualreviews.org
Population balance modeling is undergoing phenomenal growth in its applications, and this
growth is accompanied by multifarious reviews. This review aims to fortify the model's …

Using residence time distributions (RTDs) to address the traceability of raw materials in continuous pharmaceutical manufacturing

W Engisch, F Muzzio - Journal of pharmaceutical innovation, 2016 - Springer
Continuous processing in pharmaceutical manufacturing is a relatively new approach that
has generated significant attention. While it has been used for decades in other industries …

A framework of hybrid model development with identification of plant‐model mismatch

Y Chen, M Ierapetritou - AIChE Journal, 2020 - Wiley Online Library
Hybrid modeling has attracted increasing attention in order to take advantage of the
additional data to improve process understanding. Current practice often adopts mechanistic …

Digital twin of a continuous direct compression line for drug product and process design using a hybrid flowsheet modelling approach

M Moreno-Benito, KT Lee, D Kaydanov… - International Journal of …, 2022 - Elsevier
The pharmaceutical industry is continuously overcoming ways to reduce its development
times to market and bring new medicines to patients with the highest quality standards …