Actin is a key structural protein that makes up the cytoskeleton of cells, and plays a role in
functions such as division, migration, and vesicle trafficking. It comprises six different cell …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

Apoptosis is an important biological process required for the removal of unwanted or
damaged cells. Mounting evidence implicates the actin cytoskeleton as both a sensor and …

Osteopontin (OPN) is a multifunctional cytokine that is strongly expressed in healing wounds
and fibrotic lesions, both of which are characterized by the formation of myofibroblasts. We …

Objective To define the relationship between autoantigen citrullination and different
peptidylarginine deiminase (PAD) enzymes in rheumatoid arthritis (RA). Methods …

α-Smooth muscle actin (SMA), an actin isoform that contributes to cell-generated mechanical
tension, is normally restricted to cells of vascular smooth muscle, but SMA can also be …

Function of the heart begins long before its formation is complete. Analyses in mouse and
zebrafish have shown that myocardial function is not required for early steps of …

Myofibroblasts are specialized fibroblasts responsible for granulation tissue contraction and
the soft tissue retractions occurring during fibrocontractive diseases. The marker of fibroblast …

Age-related hearing loss (presbycusis) is a significant problem in the population. The
genetic contribution to age-related hearing loss is estimated to be 40%–50%. Gene …

Abstract Baraitser–Winter, Fryns–Aftimos and cerebrofrontofacial syndrome types 1 and 3
have recently been associated with heterozygous gain-of-function mutations in one of the …