The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …

Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria
have modified their virulence mechanisms to adapt to host defense systems. Although the …

Drug efflux pumps play a key role in drug resistance and also serve other functions in
bacteria. There has been a growing list of multidrug and drug-specific efflux pumps …

TolC is an archetypal member of the outer membrane efflux protein (OEP) family. These
proteins are involved in export of small molecules and toxins across the outer membrane of …

There is concern that antibiotics in the environment can select for and enrich bacteria
carrying acquired antibiotic resistance genes, thus increasing the potential of those genes to …

The widespread practice of applying sewage sludge to arable land makes use of nutrients
indispensable for crops and reduces the need for inorganic fertilizer, however this …

The need for lengthy treatment to cure tuberculosis stems from phenotypic drug resistance,
also known as drug tolerance, which has been previously attributed to slowed bacterial …

Although many typical outer‐membrane proteins (OMPs) have been well characterized, the
biological functions of many OMPs remain largely elusive. In this study, we successfully …

Pneumonia associated with Iegionnaires's disease is initiated in humans after inhalation of
contaminated aerosols. In the environment, Legionella pneumophila is thought to survive …

The extracellular proteome (secretome) of periodontitis-associated bacteria may constitute a
major link between periodontitis and systemic diseases. To obtain an overview of the …