A review of parameter settings for invasive and non-invasive vagus nerve stimulation (VNS) applied in neurological and psychiatric disorders

SL Thompson, GH O'Leary, CW Austelle… - Frontiers in …, 2021 - frontiersin.org
Vagus nerve stimulation (VNS) is an established form of neuromodulation with a long history
of promising applications. Earliest reports of VNS in the literature date to the late 1800's in …

[HTML][HTML] Primary motor cortex in Parkinson's disease: Functional changes and opportunities for neurostimulation

CF Underwood, LC Parr-Brownlie - Neurobiology of Disease, 2021 - Elsevier
Movement abnormalities of Parkinson's disease (PD) arise from disordered neural activity in
multiple interconnected brain structures. The planning and execution of movement requires …

Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice

E Siopi, M Galerne, M Rivagorda, S Saha… - Molecular …, 2023 - nature.com
Chronic stress constitutes a major risk factor for depression that can disrupt various aspects
of homeostasis, including the gut microbiome (GM). We have recently shown that GM …

[HTML][HTML] Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement

S Bowles, J Hickman, X Peng, WR Williamson… - Neuron, 2022 - cell.com
Vagus nerve stimulation (VNS) is a neuromodulation therapy for a broad and expanding set
of neurologic conditions. However, the mechanism through which VNS influences central …

[HTML][HTML] Vagus nerve stimulation induces widespread cortical and behavioral activation

L Collins, L Boddington, PJ Steffan, D McCormick - Current Biology, 2021 - cell.com
Vagus nerve stimulation (VNS) is used for management of a variety of neurological
conditions, although the therapeutic mechanisms are not fully understood. Accumulating …

[HTML][HTML] How to fail with paired VNS therapy

SA Hays, RL Rennaker II, MP Kilgard - Brain stimulation, 2023 - Elsevier
Vagus nerve stimulation (VNS) has gained enormous traction as a promising bioelectronic
therapy. In particular, the delivery of VNS paired with training to promote neural changes has …

[HTML][HTML] Noradrenergic neuromodulation in ageing and disease

F Krohn, E Lancini, M Ludwig, M Leiman… - Neuroscience & …, 2023 - Elsevier
The locus coeruleus (LC) is a small brainstem structure located in the lower pons and is the
main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates …

The peripheral effect of direct current stimulation on brain circuits involving memory

S Vanneste, A Mohan, HB Yoo, Y Huang… - Science …, 2020 - science.org
An ongoing debate surrounding transcranial direct current stimulation (tDCS) of the scalp is
whether it modulates brain activity both directly and in a regionally constrained manner …

Transauricular vagus nerve stimulation for patients with disorders of consciousness: a randomized controlled clinical trial

YF Zhou, JW Kang, Q Xiong, Z Feng… - Frontiers in …, 2023 - frontiersin.org
Introduction Disorders of consciousness (DoCs) are a frequent complication of brain injury
disease, and effective treatments are currently lacking. Transauricular vagus nerve …

Rapid effects of vagus nerve stimulation on sensory processing through activation of neuromodulatory systems

C Rodenkirch, JB Carmel, Q Wang - Frontiers in neuroscience, 2022 - frontiersin.org
After sensory information is encoded into neural signals at the periphery, it is processed
through multiple brain regions before perception occurs (ie, sensory processing). Recent …