Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

Super-resolution microscopy has overcome a long-held resolution barrier—the diffraction
limit—in light microscopy and enabled visualization of previously invisible molecular details …

Fluorescence microscopy is an invaluable tool in the biosciences, a genuine workhorse
technique offering exceptional contrast in conjunction with high specificity of labelling with …

The existence of cellular heterogeneity and its central relevance to biological phenomena
provides a strong rationale for a need for analytical methods that enable analysis at the …

RAF kinases are essential effectors of RAS, but how RAS binding initiates the
conformational changes needed for autoinhibited RAF monomers to form active dimers has …

RAS GTPases are important mediators of oncogenesis in humans. However,
pharmacological inhibition of RAS has proved challenging. Here we describe a functionally …

Combined BRAF-and MEK-targeted therapy improves upon BRAF inhibitor (BRAFi) therapy
but is still beset by acquired resistance. We show that melanomas acquire resistance to …

Super-resolution microscopy (SRM) methods have allowed scientists to exceed the
diffraction limit of light, enabling the discovery and investigation of cellular structures at the …

RAS has long been viewed as undruggable due to its lack of deep pockets for binding of
small molecule inhibitors. However, recent successes in the development of direct RAS …

Rat sarcoma (Ras) GTPases regulate cell proliferation and survival through effector
pathways including Raf-MAPK, and are the most frequently mutated genes in human cancer …