Chagas disease, caused by the Trypanosoma cruzi parasitic protozoan, is a neglected
tropical disease (NTD) of significant incidence in Latin America. Transmission to humans …

Introduction: Trypanosoma cruzi is the etiologic agent of American trypanosomiasis (Chagas
disease), which is one of the important parasitic diseases worldwide. The number of infected …

ETHNOPHARMACOLOGICAL RELEVANCE: The ethanolic extract of Lychnophora
trichocarpha Spreng. is used in Brazilian folk medicine to treat bruise, pain and inflammatory …

The drugs available for Chagas disease treatment are toxic and ineffective. We studied the
in vivo activity of a new drug, lychnopholide (LYC). LYC was loaded in nanocapsules (NC) …

Thirty-two organic and aqueous extracts, belonging to 12 Argentine medicinal plants were
tested for their in vitro trypanocidal activity on epimastigote forms of Trypanosoma cruzi …

Crude extracts from the aerial parts of Lychnophora granmongolense (Asteraceae) were
bioassayed for trypanocidal (trypomastigote forms of Trypanosoma cruzi) and analgesic …

In the continuing search for new compounds with trypanocidal activity for use in blood banks
to prevent the transmission of Chagas' disease, a trypanocidal extract of Lychnophora …

Twenty-two extracts from five Lychnophora species and one Lychnophoriopsis species,
traditionally used in Brazil as analgesic, anti-inflammatory, and to treat bruise and …

Chagas disease (CD) remains neglected and causes high morbidity and mortality. The great
difficulty is the lack of effective treatment. The current drugs cause side effects and have …

Chagas disease remains neglected, and current chemotherapeutics present severe
limitations. Lychnopholide (LYC) at low doses loaded in polymeric poly (d, l-lactide)-block …