Urinary tract infections: epidemiology, mechanisms of infection and treatment options

AL Flores-Mireles, JN Walker, M Caparon… - Nature reviews …, 2015 - nature.com
Urinary tract infections (UTIs) are a severe public health problem and are caused by a range
of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus …

Pathogenesis of Proteus mirabilis Infection

CE Armbruster, HLT Mobley, MM Pearson - EcoSal Plus, 2018 - Am Soc Microbiol
Proteus mirabilis, a Gram-negative rod-shaped bacterium most noted for its swarming
motility and urease activity, frequently causes catheter-associated urinary tract infections …

Antimicrobial efficacy of Mentha piperata-derived biogenic zinc oxide nanoparticles against UTI-resistant pathogens

N Ahmad, S Ali, M Abbas, H Fazal, S Saqib, A Ali… - Scientific reports, 2023 - nature.com
Misuse of antibiotics leads to the worldwide spread of antibiotic resistance, which motivates
scientists to create new antibiotics. The recurring UTI due to antibiotics-resistant …

Gram‐positive uropathogens, polymicrobial urinary tract infection, and the emerging microbiota of the urinary tract

KA Kline, AL Lewis - Urinary tract infections: molecular …, 2017 - Wiley Online Library
Uncomplicated urinary‐tract infection (UTI) is most common in young, sexually active,
nonpregnant, premenopausal women. Gram‐negative bacteria are isolated from 75% to …

The immune response to infection in the bladder

L Lacerda Mariano, MA Ingersoll - Nature Reviews Urology, 2020 - nature.com
The bladder is continuously protected by passive defences such as a mucus layer,
antimicrobial peptides and secretory immunoglobulins; however, these defences are …

Enzymatic modifications of exopolysaccharides enhance bacterial persistence

GB Whitfield, LS Marmont, PL Howell - Frontiers in microbiology, 2015 - frontiersin.org
Biofilms are surface-attached communities of bacterial cells embedded in a self-produced
matrix that are found ubiquitously in nature. The biofilm matrix is composed of various …

Enterococcus faecalis promotes innate immune suppression and polymicrobial catheter-associated urinary tract infection

BYQ Tien, HMS Goh, KKL Chong… - Infection and …, 2017 - Am Soc Microbiol
Enterococcus faecalis, a member of the human gastrointestinal microbiota, is an
opportunistic pathogen associated with hospital-acquired wound, bloodstream, and urinary …

Early maladaptive schemas as mediators between childhood maltreatment and later psychological distress among Chinese college students

J Gong, RCK Chan - Psychiatry research, 2018 - Elsevier
The aim of the current study was to examine whether early maladaptive schemas (EMSs)
mediate the association between different kinds of childhood maltreatment and later …

Polymicrobial interactions in the urinary tract: is the enemy of my enemy my friend?

JR Gaston, AO Johnson, KL Bair, AN White… - Infection and …, 2021 - Am Soc Microbiol
The vast majority of research pertaining to urinary tract infection has focused on a single
pathogen in isolation and predominantly Escherichia coli. However, polymicrobial urine …

Polymicrobial–host interactions during infection

WH Tay, KKL Chong, KA Kline - Journal of molecular biology, 2016 - Elsevier
Microbial pathogenesis research has, historically, focused on the study of infections as
monomicrobial events. However, the advent of next generation sequencing and culture …