Background Articular cartilage defects are a veritable therapeutic problem because
therapeutic options are very scarce. Due to the poor self-regeneration capacity of cartilage …

Osteoarthritis (OA) is one of the most prevalent chronic joint diseases worldwide, which
causes a series of problems, such as joint pain, muscle atrophy, and joint deformities …

Human cartilage is a complex tissue of matrix proteins that vary in amount and orientation
from superficial to deep layers and from loaded to unloaded zones. A major challenge to …

In osteoarthritis (OA), adult articular chondrocytes undergo phenotypic modulation in
response to alterations in the environment owing to mechanical injury and inflammation …

OBJECTIVE: Sheep and goats are commonly used large animal species for studying
pathogenesis and treatment of osteoarthritis (OA). This review focuses on the macroscopic …

Osteoarthritis (OA) is a disease of high ethical and economical importance. In advanced
stages, the patients suffer from severe pain and restriction of mobility. The consequence in …

The class of small leucine-rich proteoglycans (SLRPs) is a family of homologous
proteoglycans harboring relatively small (36–42 kDa) protein cores compared with the larger …

Objective To explore the involvement of protease‐activated receptor 1 (PAR‐1) and PAR‐2
in the pathologic processes of osteoarthritis (OA) and to identify the cells/tissues primarily …

Osteoarthritis (OA) is increasingly recognised as a disease of diverse phenotypes with
variable clinical presentation, progression, and response to therapeutic intervention. This …

The complex pathobiologic changes of human joint disease, particularly osteoarthritis (OA),
normally take several decades to develop and may be influenced by a multitude of genetic …