Cystic fibrosis (CF) is a lethal inherited disease caused by mutations in the CF
transmembrane conductance regulator (CFTR) gene, which result in impairment of CFTR …

Inflammation plays a critical role in cystic fibrosis (CF) lung pathology and disease
progression making it an active area of research and important therapeutic target. In this …

Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …

Patients with severe COVID-19, such as individuals in intensive care units (ICU), are
exceptionally susceptible to bacterial and fungal infections. The most prevalent fungal …

In cystic fibrosis (CF), deletion of phenylalanine 508 (F508del) in the CF transmembrane
conductance regulator (CFTR) is associated to misfolding and defective gating of the mutant …

Innate lymphoid cells (ILCs) are crucial for the immune surveillance at mucosal sites. ILCs
coordinate early eradication of pathogens and contribute to tissue healing and remodeling …

The relentless efforts of thousands of researchers have allowed deciphering the molecular
machinery that regulates and executes autophagy, thus identifying multiple molecular …

Cystic fibrosis (CF) is the most common monogenic disorder, caused by mutations in the CF
transmembrane conductance regulator (CFTR) gene. Over the last 30 years, tremendous …

Background COVID-19 characterized by refractory hypoxemia increases patient mortality
because of immunosuppression effects. This study aimed to evaluate the efficacy of …

Thymosin alpha1 (Tα1), an endogenous peptide first isolated from the thymic tissue in the
mid-sixties, has gained considerable attention for its immunostimulatory activity that led to its …