Implication of intestinal barrier dysfunction in gut dysbiosis and diseases

C Stolfi, C Maresca, G Monteleone, F Laudisi - Biomedicines, 2022 - mdpi.com
The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a
critical player in gut homeostasis maintenance as it ensures the complex crosstalk between …

Probiotics and gut microbiota: Mechanistic insights into gut immune homeostasis through TLR pathway regulation

H Kaur, SA Ali - Food & Function, 2022 - pubs.rsc.org
Consumption of probiotics as a useful functional food improves the host's wellbeing, and,
when paired with prebiotics (indigestible dietary fibre/carbohydrate), often benefits the host …

Stem cell-derived intestinal organoids: a novel modality for IBD

C Tian, M Yang, H Xu, M Zhu, NN Yue, Y Zhang… - Cell Death …, 2023 - nature.com
The organoids represent one of the greatest revolutions in the biomedical field in the past
decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly …

The intestinal barrier—shielding the body from nano-and microparticles in our diet

M Schwarzfischer, G Rogler - Metabolites, 2022 - mdpi.com
Nano-and microparticles are an implicit part of the human diet. They are unknowingly
ingested with our food that contains them as additives or pollutants. However, their impact …

The epithelial barrier theory: development and exacerbation of allergic and other chronic inflammatory diseases

UC Kucuksezer, C Ozdemir, D Yazici, Y Pat… - Asia Pacific …, 2023 - journals.lww.com
It is now longer than half a century, humans, animals, and nature of the world are under the
influence of exposure to many newly introduced noxious substances. These exposures are …

Exploring potential biomarkers and therapeutic targets in inflammatory bowel disease: insights from a mega-analysis approach

E Stemmer, T Zahavi, M Kellerman… - Frontiers in …, 2024 - frontiersin.org
Background Understanding the molecular pathogenesis of inflammatory bowel disease
(IBD) has led to the discovery of new therapeutic targets that are more specific and effective …

Ocular instillation of conditioned medium from mesenchymal stem cells is effective for dry eye syndrome by improving corneal barrier function

T Imaizumi, R Hayashi, Y Kudo, X Li, K Yamaguchi… - Scientific Reports, 2023 - nature.com
Dry eye syndrome (DES) is a chronic ocular disease that induces epithelial damage to the
cornea by decreasing tear production and quality. Adequate treatment options have not …

Monotropein inhibits colitis associated cancer through VDR/JAK1/STAT1 regulation of macrophage polarization

Y Lu, Y Chen, Y Li, S Xu, D Lian, J Liang… - International …, 2023 - Elsevier
Colorectal cancer (CRC) is a growing concern due to its high morbidity and mortality, and
the search for effective and less toxic active substances against inflammatory bowel …

A proteomic insight reveals the role of food-associated Lactiplantibacillus plantarum C9O4 in reverting intestinal inflammation

MC Cufaro, R Prete, F Di Marco, G Sabatini, A Corsetti… - Iscience, 2023 - cell.com
Nowadays, Western diets and lifestyle lead to an increasing occurrence of chronic gut
inflammation that represents an emerging health concern with still a lack of successful …

[HTML][HTML] Patient-derived organoids for therapy personalization in inflammatory bowel diseases

M Lucafò, A Muzzo, M Marcuzzi, L Giorio… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders of the intestinal tract
that have emerged as a growing problem in industrialized countries. Knowledge of IBD …