Forkhead box transcription factor, FOXM1 is implicated in several cellular processes such as
proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue …

Although cancer was originally considered a disease driven only by genetic mutations, it has
now been proven that it is also an epigenetic disease driven by DNA hypermethylation …

Nm (2′-O-methylation) is one of the most common modifications in the RNA world. It has
the potential to influence the RNA molecules in multiple ways, such as structure, stability …

All major biological macromolecules (DNA, RNA, proteins and lipids) undergo enzyme-
catalysed covalent modifications that impact their structure, function and stability. A variety of …

Gene fusions result from either structural chromosomal rearrangement or aberrations
caused by splicing or transcriptional readthrough. The precise and distinctive presence of …

RCC1 (regulator of chromosome condensation 1) is the only known guanine nucleotide
exchange factor of Ran, a nuclear Ras-like G protein. RCC1 combines with chromatin and …

Precise, reproducible characterization of AAV is critical for comparing preclinical results
between laboratories and determining a safe and effective clinical dose for gene therapy …

Abstract ETV6 (translocation-Ets-leukemia virus) gene is a transcriptional repressor mainly
involved in haematopoiesis and maintenance of vascular networks and has developed to be …

Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC)
tumorigenesis involves a combination of multiple genetic alteration processes. Constructing …

Despite the interest in characterizing genomic variation, the presence of large repeats at the
breakpoints hinders the analysis of many structural variants. This is especially problematic …