CCR5 as a coreceptor for human immunodeficiency virus and simian immunodeficiency viruses: a prototypic love-hate affair
AJ Jasinska, I Pandrea, C Apetrei - Frontiers in Immunology, 2022 - frontiersin.org
CCR5, a chemokine receptor central for orchestrating lymphocyte/cell migration to the sites
of inflammation and to the immunosurveillance, is involved in the pathogenesis of a wide …
of inflammation and to the immunosurveillance, is involved in the pathogenesis of a wide …
Animal models for HIV cure research
BB Policicchio, I Pandrea, C Apetrei - Frontiers in immunology, 2016 - frontiersin.org
The HIV-1/AIDS pandemic continues to spread unabated worldwide, and no vaccine exists
within our grasp. Effective antiretroviral therapy (ART) has been developed, but ART cannot …
within our grasp. Effective antiretroviral therapy (ART) has been developed, but ART cannot …
Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy
ME Schechter, BB Andrade, T He, GH Richter… - Science translational …, 2017 - science.org
In HIV infection, persistent inflammation despite effective antiretroviral therapy is linked to
increased risk of noninfectious chronic complications such as cardiovascular and …
increased risk of noninfectious chronic complications such as cardiovascular and …
The genome of the vervet (Chlorocebus aethiops sabaeus)
WC Warren, AJ Jasinska, R García-Pérez… - Genome …, 2015 - genome.cshlp.org
We describe a genome reference of the African green monkey or vervet (Chlorocebus
aethiops). This member of the Old World monkey (OWM) superfamily is uniquely valuable for …
aethiops). This member of the Old World monkey (OWM) superfamily is uniquely valuable for …
Ancient hybridization and strong adaptation to viruses across African vervet monkey populations
Vervet monkeys are among the most widely distributed nonhuman primates, show
considerable phenotypic diversity, and have long been an important biomedical model for a …
considerable phenotypic diversity, and have long been an important biomedical model for a …
The Hitchhiker Guide to CD4+ T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4+ T Cells in SIV and HIV Infection
Q Le Hingrat, I Sereti, AL Landay, I Pandrea… - Frontiers in …, 2021 - frontiersin.org
CD4+ T-cell depletion is pathognomonic for AIDS in both HIV and simian immunodeficiency
virus (SIV) infections. It occurs early, is massive at mucosal sites, and is not entirely reverted …
virus (SIV) infections. It occurs early, is massive at mucosal sites, and is not entirely reverted …
Non-human primates in HIV research: Achievements, limits and alternatives
An ideal model for HIV-1 research is still unavailable. However, infection of non-human
primates (NHP), such as macaques, with Simian Immunodeficiency Virus (SIV) recapitulates …
primates (NHP), such as macaques, with Simian Immunodeficiency Virus (SIV) recapitulates …
Epigenetic clock and methylation studies in vervet monkeys
DNA methylation-based biomarkers of aging have been developed for many mammals but
not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human …
not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human …
Morphological variation in the genus Chlorocebus: Ecogeographic and anthropogenically mediated variation in body mass, postcranial morphology, and growth
Objectives Direct comparative work in morphology and growth on widely dispersed wild
primate taxa is rarely accomplished, yet critical to understanding ecogeographic variation …
primate taxa is rarely accomplished, yet critical to understanding ecogeographic variation …
Antibiotic and antiinflammatory therapy transiently reduces inflammation and hypercoagulation in acutely SIV-infected pigtailed macaques
I Pandrea, C Xu, JL Stock, DN Frank, D Ma… - PLoS …, 2016 - journals.plos.org
Increased chronic immune activation and inflammation are hallmarks of HIV/SIV infection
and are highly correlated with progression to AIDS and development of non-AIDS …
and are highly correlated with progression to AIDS and development of non-AIDS …