Background Annuloplasty ring dehiscence is a well described mode of mitral valve repair
failure. Defining the mechanisms underlying dehiscence may facilitate its prevention …

Mitral regurgitation is a common cardiac valve lesion, developing from primary lesions of the
mitral valve or secondary to cardiomyopathies. Moderate or higher severity of mitral …

OBJECTIVES Transcatheter mitral valve repair is an emerging alternative to the surgical
repair. This technology requires preclinical studies to assess efficacy in mitigating mitral …

Annulus tension (AT) is defined as leaflet tension per unit length of the annulus
circumference. AT was investigated to understand tricuspid valve (TV) annulus mechanics …

The porcine mitral regurgitation (MR) model is a common cardiovascular animal model.
Standardized manufacturing processes can improve the uniformity and success rate of the …

Abstract Development of transcatheter mitral valve interventions has ushered a significant
need for large animal models of secondary mitral regurgitation. Though currently used heart …

Functional mitral regurgitation (FMR) is a complex pathology involving valvular and
subvalvular structures reconfiguration, and its treatment is considered challenging. There is …

Rapid preclinical evaluations of mitral valve (MV) mechanics are currently best facilitated by
bench models of the left ventricle (LV). This review aims to provide a comprehensive …

Helical anchors are used in transcatheter mitral valve repair. The aim of the current study
was to investigate effect of helical anchor design, anchored position and biting depth on the …

Transcatheter therapies are emerging for functional mitral regurgitation (FMR) treatment,
however there is lack of pathological models for their preclinical assessment. We …