Apoptosis, autophagy, NETosis, necroptosis, and pyroptosis mediated programmed cell death as targets for innovative therapy in rheumatoid arthritis

J Zhao, P Jiang, S Guo, SJ Schrodi, D He - Frontiers in immunology, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that can lead to clinical
manifestations of systemic diseases. Its leading features include chronic synovial …

Traditional herbal medicine: Therapeutic potential in rheumatoid arthritis

Y Wang, S Chen, K Du, C Liang, S Wang… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Rheumatoid arthritis (RA) is a chronic inflammatory
autoimmune disease influenced by diverse endogenous and exogenous factors. It is …

Inflammation-targeted celastrol nanodrug attenuates collagen-induced arthritis through NF-κB and Notch1 pathways

L An, Z Li, L Shi, L Wang, Y Wang, L Jin, X Shuai… - Nano Letters, 2020 - ACS Publications
Rheumatoid arthritis (RA) is a systemic inflammatory disorder which can cause bone and
cartilage damage leading to disability, yet the treatment remains unsatisfactory nowadays …

Tripterygium wilfordii: An inspiring resource for rheumatoid arthritis treatment

Y Zhang, X Mao, W Li, W Chen, X Wang… - Medicinal research …, 2021 - Wiley Online Library
Abstract Tripterygium wilfordii Hook F (TwHF)‐based therapy is among the most efficient and
crucial therapeutics for the treatment of rheumatoid arthritis (RA), which indicates that TwHF …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Prevention and treatment of inflammatory arthritis with traditional Chinese medicine: underlying mechanisms based on cell and molecular targets

W Li, L Yu, W Li, G Ge, Y Ma, L Xiao, Y Qiao… - Ageing Research …, 2023 - Elsevier
Inflammatory arthritis, primarily including rheumatoid arthritis, osteoarthritis and ankylosing
spondylitis, is a group of chronic inflammatory diseases, whose general feature is joint …

Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone‐methide triterpenoid celastrol

Y Lu, Y Liu, J Zhou, D Li, W Gao - Medicinal research reviews, 2021 - Wiley Online Library
Celastrol, a quinone‐methide triterpenoid, was extracted from Tripterygium wilfordii Hook. F.
in 1936 for the first time. Almost 70 years later, it is considered one of the molecules most …

Celastrol exerts anti‐inflammatory effect in liver fibrosis via activation of AMPK‐SIRT3 signalling

Y Wang, C Li, J Gu, C Chen, J Duanmu… - Journal of Cellular …, 2020 - Wiley Online Library
Celastrol, a pentacyclic tritepene extracted from Tripterygium Wilfordi plant, showing potent
liver protection effects on several liver‐related diseases. However, the anti‐inflammatory …

Exploring the mechanism of Celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics

L Zeng, G Yu, K Yang, Q He, W Hao, W Xiang… - Scientific Reports, 2024 - nature.com
To explore the molecular network mechanism of Celastrol in the treatment of rheumatoid
arthritis (RA) based on a novel strategy (integrated systems pharmacology, proteomics …

Up-regulation of heme oxygenase-1 by celastrol alleviates oxidative stress and vascular calcification in chronic kidney disease

X Yang, A Chen, Q Liang, Q Dong, M Fu, X Liu… - Free Radical Biology …, 2021 - Elsevier
Vascular calcification is very commonly observed in patients with chronic kidney disease
(CKD), but there is no efficient therapy available. Oxidative stress plays critical roles in the …