Bile acids, a structurally related group of molecules derived from cholesterol, have a long
history as therapeutic agents in medicine, from treatment for primarily ocular diseases in …

Ferroptosis is an iron-dependent cell death with the accumulation of lipid peroxidation and
dysfunction of antioxidant systems. As the critical regulator, glutathione peroxidase 4 (GPX4) …

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motoneurons in
the cerebral cortex, brainstem and spinal cord. Neuroinflammation plays an important role in …

Organs-on-chips are broadly defined as microfabricated surfaces or devices designed to
engineer cells into microscale tissues with native-like features and then extract …

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease
(MND), and> 95% of familial and sporadic cases involve the deposition of insoluble …

Background and Objectives: Neuroinflammation is associated with many neurodegenerative
diseases, including amyotrophic lateral sclerosis (ALS). In this study, we investigate the anti …

CNS ischemia results in locally confined and rapid tissue damage accompanied by a loss of
neurons and their circuits. Early and time-delayed inflammatory responses are critical …

Background Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa
(TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases …

Reactive astrocytes in Amyotrophic Lateral Sclerosis (ALS) change their molecular
expression pattern and release toxic factors that contribute to neurodegeneration and …

Ethnopharmacological relevance Alzheimer's disease is the most common form of dementia,
but its treatment options remain few and ineffective. To find new therapeutic strategies …