Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …

Glial cells in the peripheral nervous system (PNS), which arise from the neural crest, include
axon-associated Schwann cells (SCs) in nerves, synapse-associated SCs at the …

Here, we present evidence showing Piezo1 protein expression in the primary sensory
neurons (PSNs) and non-neuronal cells of rat peripheral nervous system. Using a …

Similar to chronic pain, chronic itch is frequently linked to neural sensitization, a
phenomenon wherein the nervous system becomes hypersensitive to stimuli. This process …

Background The brain is a highly mechanosensitive organ, and changes in the mechanical
properties of brain tissue influence many physiological and pathological processes. Piezo …

Optic nerve head (ONH) astrocytes provide structural and metabolic support to neuronal
axons in developmental, physiological, and pathological progression. Mechanosensitive …

PIEZO1 and PIEZO2 are mechanosensitive ion channels that regulate many important
physiological processes including vascular blood flow, touch, and proprioception. As the eye …

Myelinating cells are sensitive to mechanical stimuli from their extracellular matrix. Ablation
of YAP and TAZ mechanotransducers in Schwann cells abolishes the axon–Schwann cell …

Contact inhibition (CI) represents a crucial tumor-suppressive mechanism responsible for
controlling the unbridled growth of cells, thus preventing the formation of cancerous tissues …