Small molecule inhibitors targeting the heat shock protein system of human obligate protozoan parasites
Obligate protozoan parasites of the kinetoplastids and apicomplexa infect human cells to
complete their life cycles. Some of the members of these groups of parasites develop in at …
complete their life cycles. Some of the members of these groups of parasites develop in at …
Prion‐like proteins: from computational approaches to proteome‐wide analysis
Prions are self‐perpetuating proteins able to switch between a soluble state and an
aggregated‐and‐transmissible conformation. These proteinaceous entities have been …
aggregated‐and‐transmissible conformation. These proteinaceous entities have been …
Molecular descriptors property prediction using transformer-based approach
In this study, we introduce semi-supervised machine learning models designed to predict
molecular properties. Our model employs a two-stage approach, involving pre-training and …
molecular properties. Our model employs a two-stage approach, involving pre-training and …
Inhibitors of the Plasmodium falciparum Hsp90 towards Selective Antimalarial Drug Design: The Past, Present and Future
ML Stofberg, C Caillet, M de Villiers, T Zininga - Cells, 2021 - mdpi.com
Malaria is still one of the major killer parasitic diseases in tropical settings, posing a public
health threat. The development of antimalarial drug resistance is reversing the gains made …
health threat. The development of antimalarial drug resistance is reversing the gains made …
Application of yeast to studying amyloid and prion diseases
Amyloids are fibrous cross-β protein aggregates that are capable of proliferation via
nucleated polymerization. Amyloid conformation likely represents an ancient protein fold …
nucleated polymerization. Amyloid conformation likely represents an ancient protein fold …
Partners in Mischief: Functional Networks of Heat Shock Proteins of Plasmodium falciparum and Their Influence on Parasite Virulence
The survival of the human malaria parasite Plasmodium falciparum under the
physiologically distinct environments associated with their development in the cold-blooded …
physiologically distinct environments associated with their development in the cold-blooded …
Comparative structure-function features of Hsp70s of Plasmodium falciparum and human origins
The heat shock protein 70 (Hsp70) family of molecular chaperones are crucial for the
survival and pathogenicity of the main agent of malaria, Plasmodium falciparum. Hsp70 is …
survival and pathogenicity of the main agent of malaria, Plasmodium falciparum. Hsp70 is …
Effect of the aggregated protein dye YAT2150 on Leishmania parasite viability
L Román-Álamo, Y Avalos-Padilla… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
The problems associated with the drugs currently used to treat leishmaniasis, including
resistance, toxicity, and the high cost of some formulations, call for the urgent identification of …
resistance, toxicity, and the high cost of some formulations, call for the urgent identification of …
Inhibition of Plasmodium falciparum Hsp70-Hop partnership by 2-phenylthynesulfonamide
T Muthelo, V Mulaudzi, M Netshishivhe… - Frontiers in Molecular …, 2022 - frontiersin.org
Plasmodium falciparum Hsp70-1 (PfHsp70-1; PF3D7_0818900) and PfHsp90
(PF3D7_0708400) are essential cytosol localized chaperones of the malaria parasite. The …
(PF3D7_0708400) are essential cytosol localized chaperones of the malaria parasite. The …
Plasmodium falciparum Molecular Chaperones: Guardians of the Malaria Parasite Proteome and Renovators of the Host Proteome
GL Blatch - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Plasmodium falciparum is a unicellular protozoan parasite and causative agent of the most
severe form of malaria in humans. The malaria parasite has had to develop sophisticated …
severe form of malaria in humans. The malaria parasite has had to develop sophisticated …