An extensive literature on childhood adversity and neurodevelopment has emerged over the
past decade. We evaluate two conceptual models of adversity and neurodevelopment—the …

Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …

Two extant frameworks–the harshness-unpredictability model and the threat-deprivation
model–attempt to explain which dimensions of adversity have distinct influences on …

Background Transdiagnostic processes confer risk for multiple types of psychopathology
and explain the co-occurrence of different disorders. For this reason, transdiagnostic …

The study of depression in mothers in relation to transmission of risk for the development of
psychopathology in their children relies on solid foundations in the understanding of …

Adversity early in life is common and is a major risk factor for the onset of psychopathology.
Delineating the neurodevelopmental pathways by which early adversity affects mental …

Background Recent studies in both human and experimental animals have identified
fragmented and unpredictable parental and environmental signals as a novel source of …

Importance Childhood adversity (CA) is a powerful determinant of long-term physical and
mental health that is associated with elevated risk for chronic disease and psychopathology …

Children exposed to adverse childhood experiences (ACEs) and pervasive interpersonal
traumas may go on to develop PTSD and, in most cases, will further undergo a significant …

Exposure to childhood adversity has been consistently associated with poor developmental
outcomes, but it is unclear whether these associations vary across different forms of …