[HTML][HTML] Phage therapy: From biological mechanisms to future directions

SA Strathdee, GF Hatfull, VK Mutalik, RT Schooley - Cell, 2023 - cell.com
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research,
the natural predators of bacteria discovered over 100 years ago. In order to use phages …

Staphylococcal biofilm development: structure, regulation, and treatment strategies

K Schilcher, AR Horswill - Microbiology and Molecular Biology …, 2020 - Am Soc Microbiol
In many natural and clinical settings, bacteria are associated with some type of biotic or
abiotic surface that enables them to form biofilms, a multicellular lifestyle with bacteria …

Bacteriophage therapy against Pseudomonas aeruginosa biofilms: a review

Z Chegini, A Khoshbayan, M Taati Moghadam… - Annals of clinical …, 2020 - Springer
Abstract Multi-Drug Resistant (MDR) Pseudomonas aeruginosa is one of the most important
bacterial pathogens that causes infection with a high mortality rate due to resistance to …

Resistance development to bacteriophages occurring during bacteriophage therapy

F Oechslin - Viruses, 2018 - mdpi.com
Bacteriophage (phage) therapy, ie, the use of viruses that infect bacteria as antimicrobial
agents, is a promising alternative to conventional antibiotics. Indeed, resistance to antibiotics …

[HTML][HTML] Phage therapy in the resistance era: where do we stand and where are we going?

T Luong, AC Salabarria, DR Roach - Clinical therapeutics, 2020 - Elsevier
Purpose Widespread antibiotic-resistant bacteria are threatening the arsenal of existing
antibiotics. Not only are antibiotics less likely to be effective today, but their extensive use …

Phage treatment of an aortic graft infected with Pseudomonas aeruginosa

BK Chan, PE Turner, S Kim, HR Mojibian… - … medicine, and public …, 2018 - academic.oup.com
Management of prosthetic vascular graft infections caused by Pseudomonas aeruginosa
can be a significant challenge to clinicians. These infections often do not resolve with …

Current challenges and future opportunities of phage therapy

DP Pires, AR Costa, G Pinto, L Meneses… - FEMS microbiology …, 2020 - academic.oup.com
Antibiotic resistance is a major public health challenge worldwide, whose implications for
global health might be devastating if novel antibacterial strategies are not quickly …

[HTML][HTML] Synthesis and characterization of zinc oxide nanoparticles by using polyol chemistry for their antimicrobial and antibiofilm activity

PP Mahamuni, PM Patil, MJ Dhanavade… - … and biophysics reports, 2019 - Elsevier
The present investigation deals with facile polyol mediated synthesis and characterization of
ZnO nanoparticles and their antimicrobial activities against pathogenic microorganisms. The …

Phage-antibiotic synergy is driven by a unique combination of antibacterial mechanism of action and stoichiometry

C Gu Liu, SI Green, L Min, JR Clark, KC Salazar… - MBio, 2020 - Am Soc Microbiol
The continued rise in antibiotic resistance is precipitating a medical crisis. Bacteriophage
(phage) has been hailed as one possible therapeutic option to augment the efficacy of …

Synergy and Order Effects of Antibiotics and Phages in Killing Pseudomonas aeruginosa Biofilms

WN Chaudhry, J Concepcion-Acevedo, T Park… - PloS one, 2017 - journals.plos.org
In contrast to planktonic cells, bacteria imbedded biofilms are notoriously refractory to
treatment by antibiotics or bacteriophage (phage) used alone. Given that the mechanisms of …