Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …

Understanding the organizational logic of neural circuits requires deciphering the biological
basis of neuronal diversity and identity, but there is no consensus on how neuron types …

Epilepsy is one of the most common neurological disorders, yet its pathophysiology is poorly
understood due to the high complexity of affected neuronal circuits. To identify dysfunctional …

In the mammalian central nervous system, excitatory glutamatergic synapses harness
neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4 …

To correctly transfer information, neuronal networks need to continuously adjust their
synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of …

Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA‐
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …

Trafficking and biophysical properties of AMPA receptors (AMPARs) in the brain depend on
interactions with associated proteins. We identify Shisa6, a single transmembrane protein …

Regulation of AMPA receptor (AMPAR)-mediated synaptic transmission is a key mechanism
for synaptic plasticity. In the brain, AMPARs assemble with a number of auxiliary subunits …

Single-cell RNA-seq (scRNA-seq) assays are being increasingly utilized to investigate
specific hypotheses in both basic biology and clinically-applied studies. The design of most …