[HTML][HTML] Prenatal stressors in rodents: Effects on behavior

M Weinstock - Neurobiology of stress, 2017 - Elsevier
The current review focuses on studies in rodents published since 2008 and explores
possible reasons for any differences they report in the effects of gestational stress on various …

Beyond antipsychotics: a twenty-first century update for preclinical development of schizophrenia therapeutics

DL Spark, A Fornito, CJ Langmead… - Translational Psychiatry, 2022 - nature.com
Despite 50+ years of drug discovery, current antipsychotics have limited efficacy against
negative and cognitive symptoms of schizophrenia, and are ineffective—with the exception …

A comprehensive approach to modeling maternal immune activation in rodents

MC Bucknor, A Gururajan, RC Dale… - Frontiers in …, 2022 - frontiersin.org
Prenatal brain development is a highly orchestrated process, making it a very vulnerable
window to perturbations. Maternal stress and subsequent inflammation during pregnancy …

Prenatal stress disrupts social behavior, cortical neurobiology and commensal microbes in adult male offspring

TL Gur, AV Palkar, T Rajasekera, J Allen… - Behavioural brain …, 2019 - Elsevier
In utero and early neonatal exposure to maternal stress is linked with psychiatric disorders,
and the underlying mechanisms are currently being elucidated. We used a prenatal stressor …

Cognitive dysfunction in major depressive disorder. A translational review in animal models of the disease

F Darcet, AM Gardier, R Gaillard, DJ David… - Pharmaceuticals, 2016 - mdpi.com
Major Depressive Disorder (MDD) is the most common psychiatric disease, affecting millions
of people worldwide. In addition to the well-defined depressive symptoms, patients suffering …

Maternal distress and offspring neurodevelopment: challenges and opportunities for pre-clinical research models

E Fitzgerald, C Parent, MZL Kee… - Frontiers in Human …, 2021 - frontiersin.org
Pre-natal exposure to acute maternal trauma or chronic maternal distress can confer
increased risk for psychiatric disorders in later life. Acute maternal trauma is the result of …

Maternal programming of sex-specific responses to predator odor stress in adult rats

S St-Cyr, S Abuaish, S Sivanathan… - Hormones and behavior, 2017 - Elsevier
Prenatal stress mediated through the mother can lead to long-term adaptations in stress-
related phenotypes in offspring. This study tested the long-lasting effect of prenatal exposure …

Sex-dependence and comorbidities of the early-life adversity induced mental and metabolic disease risks: Where are we at?

K Reemst, SR Ruigrok, L Bleker, EFG Naninck… - Neuroscience & …, 2022 - Elsevier
Early-life adversity (ELA) is a major risk factor for developing later-life mental and metabolic
disorders. However, if and to what extent ELA contributes to the comorbidity and sex …

Therapeutic inducers of the HSP 70/HSP 110 protect mice against traumatic brain injury

B Eroglu, DE Kimbler, J Pang, J Choi… - Journal of …, 2014 - Wiley Online Library
Traumatic brain injury (TBI) induces severe harm and disability in many accident victims and
combat‐related activities. The heat‐shock proteins Hsp70/Hsp110 protect cells against …

Prenatal maternal factors in the development of cognitive impairments in the offspring

J Richetto, MA Riva - Journal of reproductive immunology, 2014 - Elsevier
Different environmental factors acting during sensitive prenatal periods can have a negative
impact on neurodevelopment and predispose the individual to the development of various …