Human NK cells: surface receptors, inhibitory checkpoints, and translational applications
NK cells play important roles in innate defenses against viruses and in the control of tumor
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …
The role of decidual immune cells on human pregnancy
The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and
develop in the uterus, despite being recognized by the maternal immune cells. Within the …
develop in the uterus, despite being recognized by the maternal immune cells. Within the …
Clonal expansion and epigenetic inheritance of long-lasting NK cell memory
Clonal expansion of cells with somatically diversified receptors and their long-term
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …
Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells
Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged
receptors, a hallmark of adaptive lymphocytes. In some people infected with human …
receptors, a hallmark of adaptive lymphocytes. In some people infected with human …
Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells
T Kamiya, SV Seow, D Wong… - The Journal of …, 2019 - Am Soc Clin Investig
A key mechanism of tumor resistance to immune cells is mediated by expression of peptide-
loaded HLA class I molecule (HLA-E) in tumor cells, which suppresses NK cell activity via …
loaded HLA class I molecule (HLA-E) in tumor cells, which suppresses NK cell activity via …
Trained memory of human uterine NK cells enhances their function in subsequent pregnancies
M Gamliel, D Goldman-Wohl, B Isaacson, C Gur… - Immunity, 2018 - cell.com
Natural killer cells (NKs) are abundant in the human decidua, regulating trophoblast
invasion and angiogenesis. Several diseases of poor placental development are associated …
invasion and angiogenesis. Several diseases of poor placental development are associated …
Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy
Modulating immune inhibitory pathways has been a major recent breakthrough in cancer
treatment. Checkpoint blockade antibodies targeting cytotoxic T-lymphocyte antigen 4 …
treatment. Checkpoint blockade antibodies targeting cytotoxic T-lymphocyte antigen 4 …
Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection
S Lopez-Vergès, JM Milush… - Proceedings of the …, 2011 - National Acad Sciences
During human CMV infection, there is a preferential expansion of natural killer (NK) cells
expressing the activating CD94–NKG2C receptor complex, implicating this receptor in the …
expressing the activating CD94–NKG2C receptor complex, implicating this receptor in the …
Natural killer cell specificity for viral infections
Natural killer (NK) cells are lymphocytes that contribute to the early immune responses to
viruses. NK cells are innate immune cells that do not express rearranged antigen receptors …
viruses. NK cells are innate immune cells that do not express rearranged antigen receptors …
Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function
B Foley, S Cooley, MR Verneris, M Pitt… - Blood, The Journal …, 2012 - ashpublications.org
During mouse cytomegalovirus (CMV) infection, a population of Ly49H+ natural killer (NK)
cells expands and is responsible for disease clearance through the induction of a “memory …
cells expands and is responsible for disease clearance through the induction of a “memory …