Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

Primary cilia are hair-like organelles and play crucial roles in vertebrate development,
organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory …

Mechanical loading is essential for chondrocyte health. Chondrocytes can sense and
respond to various extracellular mechanical signals through an integrated set of …

Primary cilia are specialized cell-surface organelles that mediate sensory perception and, in
contrast to motile cilia and flagella, are thought to lack motility function. Here, we show that …

Pancreatic islets regulate glucose homeostasis through coordinated actions of hormone-
secreting cells. What underlies the function of the islet as a unit is the close approximation …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-
threatening monogenic renal disease. ADPKD results from mutations in either of two …

Mutations in the polycystins PC1 or PC2 cause autosomal dominant polycystic kidney
disease (ADPKD), which is characterized by the formation of fluid-filled renal cysts that …

The primary cilium (PC) is a microtubule-based tiny sensory organelle emanating from the
centrosome and protruding from the surface of most eukaryotic cells, including neurons. The …

Somatostatin is a paracrine modulator of insulin secretion and beta cell function with
pleotropic effects on glucose homeostasis. The mechanism of somatostatin-mediated …

Cartilage is a connective tissue in the skeletal system and has limited regeneration ability
and unique biomechanical reactivity. The growth and development of cartilage can be …