Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

Thiolated chitosan (CS-NAC) was synthesized and the selected CS-NAC was used together
with silk fibroin (SF) to produce dual network CS-NAC/SF hydrogels. The CS-NAC/SF …

Poloxamer was grafted onto alginate and the optimally synthesized alginate-poloxamer
(ALG-POL) copolymer was combined with silk fibroin (SF) to produce thermosensitive ALG …

Cartilage is a tissue with limited self-healing potential. Hence, cartilage defects require
surgical attention to prevent or postpone the development of osteoarthritis. For cell-based …

Osteoarthritis (OA) is a chronic, degenerative joint disease primarily characterised by
damage to the articular cartilage, synovitis and persistent pain, and has become one of the …

The extracellular matrix is a dynamic and active component of the mesenchymal stem cell
niche, which controls their differentiation and self-renewal. Traditional in vitro culture …

The rotator cuff repaired construct must establish a contiguous and functioning tendon-bone
junction to provide adequate stability. However, fibrocartilage deficiency and bone loss were …

An emulsification method was developed for fabricating core-shell microspheres with a thick
shell layer. Kartogenin (KGN) and platelet-derived growth factor BB (PDGF-BB) were …

Due to the limited self-repair capacity of articular cartilage, the surgical restoration of
defective cartilage remains a major clinical challenge. The cell-based approach, which is …

The definition of quality controls for cell therapy and engineered product manufacturing
processes is critical for safe, effective, and standardized clinical implementation. Using the …