Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …

Cancer is caused by the accumulation of genetic alterations and therefore has been
historically considered to be irreversible. Intriguingly, several studies have reported that …

Developing effective drugs for Alzheimer's disease (AD), the most common cause of
dementia, has been difficult because of complicated pathogenesis. Here, we report an …

Biphasic amplitude dynamics (BAD) of oscillation have been observed in many biological
systems. However, the specific topology structure and regulatory mechanisms underlying …

The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback
mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin …

Myocardial infarction (MI) dampens heart function and poses a great health risk. The class III
deacetylase sirtuin 1 (SIRT1) is known to confer cardioprotection. SIRT1 expression is …

Basal-like breast cancer is the most aggressive breast cancer subtype with the worst
prognosis. Despite its high recurrence rate, chemotherapy is the only treatment for basal-like …

Quantitative mismatches between human physiology and experimental models can be
problematic for the development of effective therapeutics. When the effects of drugs on …

Chemokines are small secreted proteins with chemoattractant properties that play a key role
in inflammation. One such chemokine, Stromal cell-derived factor-1 (SDF-1) also known as …

Ample evidence identifies strong links between major depressive disorder (MDD) and both
risk of ischemic or coronary heart disease (CHD) and resultant morbidity and mortality. The …