Current knowledge and future perspectives of exosomes as nanocarriers in diagnosis and treatment of diseases

Z Zou, H Li, G Xu, Y Hu, W Zhang… - International Journal of …, 2023 - Taylor & Francis
Exosomes, as natural nanocarriers, characterized with low immunogenicity, non-cytotoxicity
and targeted delivery capability, which have advantages over synthetic nanocarriers …

Fluorescent, phosphorescent, magnetic resonance contrast and radioactive tracer labelling of extracellular vesicles

K Wardhani, A Levina, GER Grau, PA Lay - Chemical Society Reviews, 2024 - pubs.rsc.org
This review focusses on the significance of fluorescent, phosphorescent labelling and
tracking of extracellular vesicles (EVs) for unravelling their biology, pathophysiology, and …

Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3

D Rufino-Ramos, PR Albuquerque, K Leandro… - Molecular Therapy, 2023 - cell.com
Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3) is the most common
autosomal dominantly inherited ataxia worldwide. It is caused by an over-repetition of the …

Snorkel‐tag based affinity chromatography for recombinant extracellular vesicle purification

MR Bobbili, A Görgens, Y Yan, S Vogt… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are lipid nanoparticles and play an important role in cell‐cell
communications, making them potential therapeutic agents and allowing to engineer for …

Imaging platforms to dissect the in vivo communication, biodistribution and controlled release of extracellular vesicles

A Banerjee, M Lino, C Jesus, Q Ribeiro… - Journal of Controlled …, 2023 - Elsevier
Extracellular vesicles (EVs) work as communication vehicles, allowing the exchange of
bioactive molecules (microRNAs, mRNAs, proteins, etc) between neighbouring and distant …

Exosomes in cardiovascular disease: from mechanism to therapeutic target

AB Reiss, S Ahmed, M Johnson, U Saeedullah… - Metabolites, 2023 - mdpi.com
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. In
recent decades, clinical research has made significant advances, resulting in improved …

Advances in purification, modification, and application of extracellular vesicles for novel clinical treatments

Y Matsuzaka, R Yashiro - Membranes, 2022 - mdpi.com
Extracellular vesicles (EV) are membrane vesicles surrounded by a lipid bilayer membrane
and include microvesicles, apoptotic bodies, exosomes, and exomeres. Exosome …

Investigational use of mesenchymal stem/stromal cells and their secretome as add-on therapy in severe respiratory virus infections: challenges and perspectives

S Mattoli, M Schmidt - Advances in Therapy, 2023 - Springer
Serious manifestations of respiratory virus infections such as influenza and coronavirus
disease 2019 (COVID-19) are associated with a dysregulated immune response and …

The biodistribution of placental and fetal extracellular vesicles during pregnancy following placentation

M Kang, C Blenkiron, LW Chamley - Clinical Science, 2023 - portlandpress.com
Human pregnancy is a highly orchestrated process requiring extensive cross-talk between
the mother and the fetus. Extracellular vesicles released by the fetal tissue, particularly the …

One-minute iodine isotope labeling technology enables noninvasive tracking and quantification of extracellular vesicles in tumor lesions and intact animals

Q Guo, C Zhao, X Gao, L Ding, P Wang… - Molecular …, 2023 - ACS Publications
Real-time monitoring of the biological behavior of extracellular vesicles (EVs) in vivo is
limited, which hinders its application in biomedicine and clinical translation. A noninvasive …