[HTML][HTML] Comprehensive structural and molecular comparison of spike proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and their interactions with ACE2
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has recently emerged
in China and caused a disease called coronavirus disease 2019 (COVID-19). The virus …
in China and caused a disease called coronavirus disease 2019 (COVID-19). The virus …
Animal models for COVID-19: advances, gaps and perspectives
C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - Signal transduction and …, 2022 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …
Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin …
The novel coronavirus outbreak (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) represents the actual greatest global public health crisis. The …
coronavirus 2 (SARS-CoV-2) represents the actual greatest global public health crisis. The …
Oral antiviral treatments for COVID-19: opportunities and challenges
L Rahmah, SO Abarikwu, AG Arero, M Essouma… - Pharmacological …, 2022 - Springer
The use of antiviral COVID-19 medications can successfully inhibit SARS-CoV-2 replication
and prevent disease progression to a more severe form. However, the timing of antiviral …
and prevent disease progression to a more severe form. However, the timing of antiviral …
In silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for virus origin
The devastating impact of the COVID-19 pandemic caused by SARS–coronavirus 2 (SARS-
CoV-2) has raised important questions about its origins and the mechanism of its transfer to …
CoV-2) has raised important questions about its origins and the mechanism of its transfer to …
Natural flavonoids as potential angiotensin-converting enzyme 2 inhibitors for anti-SARS-CoV-2
M Muchtaridi, M Fauzi, NK Khairul Ikram… - Molecules, 2020 - mdpi.com
Over the years, coronaviruses (CoV) have posed a severe public health threat, causing an
increase in mortality and morbidity rates throughout the world. The recent outbreak of a …
increase in mortality and morbidity rates throughout the world. The recent outbreak of a …
[HTML][HTML] Molecular docking analysis of rutin reveals possible inhibition of SARS-CoV-2 vital proteins
Background and aim COVID-19 emerged by the end of 2019 in Wuhan, China. It spreaded
and became a public health emergency all over the world by mid of April 2020. Flavonoids …
and became a public health emergency all over the world by mid of April 2020. Flavonoids …
Quercetin and luteolin are single-digit micromolar inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase
F Munafò, E Donati, N Brindani, G Ottonello… - Scientific Reports, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a
global health pandemic. Among the viral proteins, RNA-dependent RNA polymerase (RdRp) …
global health pandemic. Among the viral proteins, RNA-dependent RNA polymerase (RdRp) …
Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses
Coronaviridae is a peculiar viral family, with a very large RNA genome and characteristic
appearance, endowed with remarkable tendency to transfer from animals to humans. Since …
appearance, endowed with remarkable tendency to transfer from animals to humans. Since …
[HTML][HTML] Approaches towards fighting the COVID‑19 pandemic
Abstract The coronavirus disease 2019 (COVID‑19) outbreak, which has caused> 46
millions confirmed infections and> 1.2 million coronavirus related deaths, is one of the most …
millions confirmed infections and> 1.2 million coronavirus related deaths, is one of the most …