[HTML][HTML] Cellular and functional heterogeneity of the airway epithelium

JD Davis, TP Wypych - Mucosal immunology, 2021 - Elsevier
The airway epithelium protects us from environmental insults, which we encounter with
every breath. Not only does it passively filter large particles, it also senses potential danger …

International consensus statement on allergy and rhinology: allergic rhinitis

SK Wise, SY Lin, E Toskala, RR Orlandi… - International forum of …, 2018 - Wiley Online Library
Background Critical examination of the quality and validity of available allergic rhinitis (AR)
literature is necessary to improve understanding and to appropriately translate this …

[HTML][HTML] The microbiota of the respiratory tract: gatekeeper to respiratory health

WH Man, WAA de Steenhuijsen Piters… - Nature Reviews …, 2017 - nature.com
The respiratory tract is a complex organ system that is responsible for the exchange of
oxygen and carbon dioxide. The human respiratory tract spans from the nostrils to the lung …

Epithelial barriers in allergy and asthma

PW Hellings, B Steelant - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
The respiratory epithelium provides a physical, functional, and immunologic barrier to
protect the host from the potential harming effects of inhaled environmental particles and to …

Redox biology of respiratory viral infections

OA Khomich, SN Kochetkov, B Bartosch, AV Ivanov - Viruses, 2018 - mdpi.com
Respiratory viruses cause infections of the upper or lower respiratory tract and they are
responsible for the common cold—the most prevalent disease in the world. In many cases …

Cellular and molecular mechanisms of allergic asthma

ZI Komlósi, W van de Veen, N Kovács, G Szűcs… - Molecular aspects of …, 2022 - Elsevier
Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …

Epithelial cell dysfunction, a major driver of asthma development

IH Heijink, VNS Kuchibhotla, MP Roffel, T Maes… - Allergy, 2020 - Wiley Online Library
Airway epithelial barrier dysfunction is frequently observed in asthma and may have
important implications. The physical barrier function of the airway epithelium is tightly …

Role of viral infections in the development and exacerbation of asthma in children

T Jartti, JE Gern - Journal of Allergy and Clinical Immunology, 2017 - Elsevier
Viral infections are closely linked to wheezing illnesses in children of all ages. Respiratory
syncytial virus (RSV) is the main causative agent of bronchiolitis, whereas rhinovirus (RV) is …

More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis

A Frey, LP Lunding, JC Ehlers, M Weckmann… - Frontiers in …, 2020 - frontiersin.org
Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …

Epithelial barrier dysfunction in chronic respiratory diseases

FM Carlier, C de Fays, C Pilette - Frontiers in physiology, 2021 - frontiersin.org
Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …