Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
The life of pi star: exploring the exciting and forbidden worlds of the benzophenone photophore
G Dorman, H Nakamura, A Pulsipher… - Chemical …, 2016 - ACS Publications
The widespread applications of benzophenone (BP) photochemistry in biological chemistry,
bioorganic chemistry, and material science have been prominent in both academic and …
bioorganic chemistry, and material science have been prominent in both academic and …
Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells
M Soethoudt, SC Stolze, MV Westphal… - Journal of the …, 2018 - ACS Publications
Chemical tools and methods that report on G protein-coupled receptor (GPCR) expression
levels and receptor occupancy by small molecules are highly desirable. We report the …
levels and receptor occupancy by small molecules are highly desirable. We report the …
Optical Control of Cannabinoid Receptor 2-Mediated Ca2+ Release Enabled by Synthesis of Photoswitchable Probes
Cannabinoid receptor 2 (CB2) is a promising target for the treatment of neuroinflammation
and other diseases. However, a lack of understanding of its complex signaling in cells and …
and other diseases. However, a lack of understanding of its complex signaling in cells and …
Synthesis of CBD and its derivatives bearing various C4′-side chains with a late-stage diversification method
X Gong, C Sun, MA Abame, W Shi, Y Xie… - The Journal of …, 2019 - ACS Publications
A novel synthetic route for making (−)-CBD and its derivatives bearing various C4′-side
chains is developed by a late-stage diversification method. Starting from commercially …
chains is developed by a late-stage diversification method. Starting from commercially …
[HTML][HTML] Druggable lipid binding sites in pentameric ligand-gated ion channels and transient receptor potential channels
WWL Cheng, MJ Arcario, JT Petroff - Frontiers in Physiology, 2022 - frontiersin.org
Lipids modulate the function of many ion channels, possibly through direct lipid-protein
interactions. The recent outpouring of ion channel structures by cryo-EM has revealed many …
interactions. The recent outpouring of ion channel structures by cryo-EM has revealed many …
[HTML][HTML] Synthesis and properties of fully-conjugated indacenedithiophenes
BS Young, DT Chase, JL Marshall, CL Vonnegut… - Chemical …, 2014 - pubs.rsc.org
The synthesis and characterization of four fully-conjugated indacenedithiophenes (IDTs) are
disclosed. In contrast to anthradithiophenes, regioselective synthesis of both syn and anti …
disclosed. In contrast to anthradithiophenes, regioselective synthesis of both syn and anti …
Synthesis of Chiral Polycyclic Tetrahydrocarbazoles by Enantioselective Aminocatalytic Double Activation of 2-Hydroxycinnamaldehydes with Dienals
YC Ming, XJ Lv, M Liu, YK Liu - Organic Letters, 2021 - ACS Publications
An efficient aminocatalytic enantioselective double-activation strategy has been developed
that combines several different aminocatalytic modes in a cascade process, such as iminium …
that combines several different aminocatalytic modes in a cascade process, such as iminium …
2012 Division of medicinal chemistry award address. Trekking the cannabinoid road: a personal perspective
A Makriyannis - Journal of medicinal chemistry, 2014 - ACS Publications
My involvement with the field of cannabinoids spans close to 3 decades and covers a major
part of my scientific career. It also reflects the robust progress in this initially largely …
part of my scientific career. It also reflects the robust progress in this initially largely …
Organocatalytic [3+ 2] cycloaddition of oxindole-based azomethine ylides with 3-nitrochromenes: a facile approach to enantioenriched polycyclic spirooxindole …
S Wu, G Zhu, S Wei, H Chen, J Qu… - Organic & Biomolecular …, 2018 - pubs.rsc.org
An organocatalytic asymmetric [3+ 2] cycloaddition of oxindole-based azomethine ylides
with 3-nitro-2H-chromenes has been developed. This reaction provides a facile approach to …
with 3-nitro-2H-chromenes has been developed. This reaction provides a facile approach to …