A considerable number of human diseases have an inflammatory component, and a key
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …

Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

Birch and colleagues have developed an important and useful framework for evaluating the
evidence for sentience–namely, the capacity to experience pain, distress and suffering, in …

Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity, and increased neuronal responsiveness in central pain pathways after painful …

Rodents are commonly used to study the pathophysiological mechanisms of pain as studies
in humans may be difficult to perform and ethically limited. As pain cannot be directly …

Distinct types of dorsal root ganglion sensory neurons may have unique contributions to
chronic pain. Identification of primate sensory neuron types is critical for understanding the …

The innate immune regulator STING is a critical sensor of self-and pathogen-derived DNA.
DNA sensing by STING leads to the induction of type-I interferons (IFN-I) and other …

Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Objectives: This review presents and discusses basic science findings and scientific
evidence generated within the last 2 decades in the field of acute postoperative pain …

Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …