With the rising prevalence of obesity has come an increasing awareness of its impact on
communicable disease. As a consequence of the 2009 H1N1 influenza A virus pandemic …

Nicotinamide adenine dinucleotide (NAD+) is a central metabolite involved in energy and
redox homeostasis as well as in DNA repair and protein deacetylation reactions …

High fat diet-induced changes in gut microbiota have been linked to intestinal permeability
and metabolic endotoxemia, which is related to metabolic disorders. However, the influence …

Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance, the
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …

Key points We recently found that feeding healthy mice a diet with reduced levels of
branched-chain amino acids (BCAAs), which are associated with insulin resistance in both …

Metabolic derangement with poor glycemic control accompanying overweight and obesity is
associated with chronic low-grade inflammation and hyperinsulinemia. Macrophages, which …

Age-related macular degeneration (AMD) is a complex multifactorial disease and the
primary cause of legal and irreversible blindness among individuals aged≥ 65 years in …

Despite studies implicating adipose tissue T cells (ATT) in the initiation and persistence of
adipose tissue inflammation, fundamental gaps in knowledge regarding ATT function …

Over the past two decades, evidence has accumulated that neurogenesis can occur in both
the juvenile and adult mammalian hypothalamus. Levels of hypothalamic neurogenesis can …

Obesity as part of metabolic syndrome is a major lifestyle disorder throughout the world.
Current drug treatments for obesity produce small and usually unsustainable decreases in …