Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …

The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …

The involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of
debate, in large part because of the lack of insight into underlying mechanisms. Here we …

Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have
come to be defined as chromatin structures that establish the assembly site for the complex …

Background Centromeres are essential for chromosome segregation, yet their DNA
sequences evolve rapidly. In most animals and plants that have been studied, centromeres …

Although it was nearly 70 years ago when transposable elements (TEs) were first
discovered “jumping” from one genomic location to another, TEs are now recognized as …

The histone H3 variant CenH3, called CENP-A in humans, is central in centromeric
chromatin to ensure proper chromosome segregation. In the absence of an underlying DNA …

The assembly of just a single kinetochore at the centromere of each sister chromatid is
essential for accurate chromosome segregation during cell division. Surprisingly, despite …

Human centromeres are defined by alpha satellite DNA arrays that are distinct and
chromosome specific. Most human chromosomes contain multiple alpha satellite arrays that …

ATRX (a lpha t halassemia/mental r etardation syndrome X-linked) belongs to the
SWI2/SNF2 family of chromatin remodeling proteins. Besides the ATPase/helicase domain …