Ovarian cancer is one of the most dangerous gynecologic malignancies showing a high
fatality rate because of late diagnosis and relapse occurrence due to chemoresistance …

NAD (P) H: quinone oxidoreductase 1 (NQO1) is a two-electron reductase responsible for
detoxification of quinones and also bioactivation of certain quinones. It is abnormally …

Nicotinamide adenine dinucleotide (NAD) is a cofactor of many enzymatic reactions as well
as being a substrate for a number of NAD-consuming enzymes (eg, PARPS, sirtuins, etc) …

Metabolic reprogramming is a hallmark of cancer metastasis in which cancer cells
manipulate their metabolic profile to meet the dynamic energetic requirements of the tumor …

Tumor cells have increased requirements for NAD+. Thus, many cancers exhibit an
increased reliance on NAD+ production pathways. This dependence may be exploited …

Background Pancreatic ductal adenocarcinomas (PDA) activate a glutamine-dependent
pathway of cytosolic nicotinamide adenine dinucleotide phosphate (NADPH) production to …

Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor, but it also acts as a
substrate for NAD-consuming enzymes, regulating cellular events such as DNA repair and …

Abstract β-Lapachone (β-lap, 1), an ortho-naphthoquinone natural product isolated from the
lapacho tree (Tabebuia avellanedae) in many regions of South America, has received …

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme for various
physiological processes including energy metabolism, DNA repair, cell growth, and cell …

Therapeutic drugs that block DNA repair, including poly (ADP-ribose) polymerase (PARP)
inhibitors, fail due to lack of tumor-selectivity. When PARP inhibitors and β-lapachone are …