Summary 22q11. 2 deletion syndrome is characterised by a well defined microdeletion that
is associated with a high risk of neuropsychiatric disorders, including intellectual disability …

The differences in cognitive processes driven by biological sex are the issues that have
gotten growing attention recently. Considering the increasing population suffering from …

Abstract Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation
of catechol substrates, classically in catecholamine metabolism, but also acting upon other …

The dopamine D2 and D3 receptors are implicated in schizophrenia and its
pharmacological treatments. These receptors undergo intracellular trafficking processes that …

ADHD, schizophrenia and bipolar disorder are psychiatric diseases with a strong genetic
component which share dopaminergic alterations. Dopamine transporter (DAT) genetics …

Background Morphoanatomical MRI methods have recently begun to be applied in the
mouse. However, substantial differences in the anatomical organisation of human and …

Sex differences in schizophrenia are apparent in almost all features of the illness, from
incidence and mean age of onset to symptomatology, course of illness and response to …

Abstract Catecholamine-O-methyltransferase (COMT) is a polymorphic gene whose variants
affect enzymatic activity and pain sensitivity via adrenergic pathways. Although COMT …

Treatment-resistant schizophrenia (TRS) continues to be a challenge. It was related to
different factors, including alterations in the activity of brain dopaminergic system, which …

Aim Premorbid cognitive impairments are observed prior to the onset of schizophrenia.
Catechol-O-methyltransferase (COMT) rs4680 is associated with psychosis and plays a …