Phagocytosis is a remarkably complex and versatile process: it contributes to innate
immunity through the ingestion and elimination of pathogens, while also being central to …

The cardiovascular system is subject to hyperlipidaemic, inflammatory, and pro-oxidant
stressors. Over time, these factors drive prevalent chronic diseases, of which atherosclerosis …

Monomeric serum immunoglobulin A (IgA) can contribute to the development of various
autoimmune diseases, but the regulation of serum IgA effector functions is not well defined …

Dengue virus (DENV) infection in the presence of reactive, non-neutralizing immunoglobulin
G (IgG)(RNNIg) is the greatest risk factor for dengue hemorrhagic fever (DHF) or dengue …

Antibodies produced in response to a foreign antigen are characterized by polyclonality, not
only in the diverse epitopes to which their variable domains bind but also in the various …

Virus-like particles (VLPs) have been shown to be strong activators of dendritic cells (DCs).
DCs are the most potent antigen presenting cells (APCs) and their activation prompts the …

Here, we review the current state of the art in analytical and structural methods used to
characterize therapeutic monoclonal antibodies (mAbs) and derivatives. First, a general …

IgG glycosylation is currently at the forefront of both immunology and glycobiology, likely due
in part to the widespread and growing use of antibodies as drugs. For over four decades, it …

Fine structural details of glycans attached to the conserved N-glycosylation site significantly
not only affect function of individual immunoglobulin G (IgG) molecules but also mediate …

Activation of the humoral immune system is initiated when antibodies recognize an antigen
and trigger effector functions through the interaction with Fc engaging molecules. The most …