α-lipoic acid (ALA, thioctic acid) is an organosulfur component produced from plants,
animals, and humans. It has various properties, among them great antioxidant potential and …

In contrast to the multiple disease-modifying therapies that are available for relapsing–
remitting multiple sclerosis (MS), the therapeutic options for progressive MS (PMS) are …

Heavy metals, which have widespread environmental distribution and originate from natural
and anthropogenic sources, are common environmental pollutants. In recent decades, their …

This review summarizes the literature describing the molecular mechanisms of arsenic-
induced oxidative stress, its relevant biomarkers, and its relation to various diseases …

Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging
supplements, and even pet food. It is well-defined as a therapy for preventing diabetic …

In both type 1 and type 2 diabetes, the late diabetic complications in nerve, vascular
endothelium, and kidney arise from chronic elevations of glucose and possibly other …

The brain is a metabolically active organ exhibiting high oxygen consumption and robust
production of reactive oxygen species (ROS). The large amounts of ROS are kept in check …

Abstract α-Lipoic acid (LA; 5-(1, 2-dithiolan-3-yl) pentanoic acid) was originally isolated from
bovine liver by Reed et al. in 1951. LA was once considered a vitamin. Subsequently, it was …

Autoxidation in food and biological systems is responsible for a multitude of adverse effects
and implications in human health as well as in food stability and preservation. Antioxidants …

Oxidative stress contributes to the pathophysiology of exposure to heavy metals/metalloid.
Beneficial renal effects of some medications, such as chelation therapy depend at least …