Dendrimers in drug research

U Boas, PMH Heegaard - Chemical Society Reviews, 2004 - pubs.rsc.org
Dendrimers are versatile, derivatisable, well-defined, compartmentalised chemical polymers
with sizes and physicochemical properties resembling those of biomolecules eg proteins …

Strategies for targeting protein–protein interactions with synthetic agents

H Yin, AD Hamilton - Angewandte Chemie International Edition, 2005 - Wiley Online Library
The development of small‐molecule modulators of protein–protein interactions is a
formidable goal, albeit one that possesses significant potential for the discovery of novel …

Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells

L Yi, Z Li, K Yuan, X Qu, J Chen, G Wang… - Journal of …, 2004 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS,
which caused a global panic in 2003. We describe here the screening of Chinese herbal …

Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms

AO Adedeji, W Severson, C Jonsson, K Singh… - Journal of …, 2013 - Am Soc Microbiol
Severe acute respiratory syndrome (SARS) is an infectious and highly contagious disease
that is caused by SARS coronavirus (SARS-CoV) and for which there are currently no …

Withanone from Withania somnifera may inhibit novel coronavirus (COVID-19) entry by disrupting interactions between viral S-protein receptor binding domain and …

A Balkrishna, S Pokhrel, J Singh, A Varshney - 2020 - researchsquare.com
Background Newly emerged COVID-19 has been shown to engage the host cell ACE2
through its spike protein receptor binding domain (RBD). Here we show that natural …

[PDF][PDF] Pharmaceutical applications of dendrimers: promising nanocarriers for drug delivery

Y Cheng, J Wang, T Rao, X He, T Xu - Front Biosci, 2008 - article.imrpress.com
Introduction 3. Delivery of non-steroidal anti-inflammatory drugs by dendrimers 3.1. Non-
covalent complexation of NSAIDs 3.2. Covalent conjugation of NSAIDs 4. Delivery of anti …

[图书][B] Synthetic multivalent molecules: concepts and biomedical applications

S Choi - 2004 - books.google.com
This book provides basic principles of multivalent interactions found in biological systems as
well as an up-to-date and thorough coverage in design concepts, syntheses, and biological …

Respiratory syncytial virus-neutralizing monoclonal antibodies motavizumab and palivizumab inhibit fusion

K Huang, L Incognito, X Cheng, ND Ulbrandt… - Journal of …, 2010 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is a major cause of virus-induced respiratory disease and
hospitalization in infants. Palivizumab, an RSV-neutralizing monoclonal antibody, is used …

Antiviral drugs specific for coronaviruses in preclinical development

AO Adedeji, SG Sarafianos - Current opinion in virology, 2014 - Elsevier
Highlights•Coronaviruses are RNA viruses that cause systemic diseases in humans and
animals.•There are no approved drugs for the treatment of coronavirus infections.•Several …

[图书][B] Polymers in drug delivery

IF Uchegbu, AG Schatzlein - 2006 - books.google.com
In recent years there has been an explosion in the use of polymers to solve various
biomedical problems. Polymers play a crucial role in controlling drug release rate …