Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of
gene control in humans. It provides cells with the opportunity to create protein isoforms of …

The protein aggregation that occurs in neurodegenerative diseases is classically thought to
occur as an undesirable, nonfunctional byproduct of protein misfolding. This model contrasts …

Following years of rapid progress identifying the genetic underpinnings of amyotrophic
lateral sclerosis (ALS) and related diseases such as frontotemporal dementia (FTD) …

The cellular response to changes in the surrounding environment and to stress requires the
coregulation of gene networks aiming to conserve energy and resources. This is often …

The response of cells to changes in their environment often requires coregulation of gene
networks, but little is known about how this can occur at the post-transcriptional level. An …

The regulation of alternative splicing involves interactions between RNA-binding proteins
and pre-mRNA positions close to the splice sites. T-cell intracellular antigen 1 (TIA1) and …

To respond adequately to oxidative stress, mammalian cells elicit rapid and tightly controlled
changes in gene expression patterns. Besides alterations in the subsets of transcribed …

In 2007, 1179 papers were published that involved the application of optical biosensors.
Reported developments in instrument hardware, assay design, and immobilization …

Cellular senescence is a complex biological process that leads to irreversible cell-cycle
arrest. Various extrinsic and intrinsic insults are associated with the onset of cellular …

Gene expression patterns in cancer cells are strongly influenced by posttranscriptional
mechanisms. RNA‐binding proteins (RBPs) play key roles in posttranscriptional gene …