M tivities seem to work in concert to maintain a nonrandom ANY STUDIES HAVE led to the
concept that membrane phospholipid asymmetry is ubiquitous. In gen- transbilayer …

Discoveries in cancer research are rarely so exceptional that they both cause immediate
changes in the treatment of patients and dramatically advance our understanding of the …

Background All-trans-retinoic acid induces complete remission in acute promyelocytic
leukemia. However, it is not clear whether induction therapy with all-trans-retinoic acid is …

The incidence of early death in a large population of unselected patients with acute
promyelocytic leukemia (APL) remains unknown because of the paucity of outcome data …

▪ Objective: To describe a novel complication of therapy with all-trans retinoic acid in patients
with acute promyelocytic leukemia.▪ Design: Case series.▪ Setting: Comprehensive cancer …

All transretinoic acid (ATRA) followed by daunorubicin (DNR)-AraC chemotherapy (CT) has
improved the outcome of acute promyelocytic leukemia (APL) by comparison to CT alone. In …

Thrombosis is a frequent complication of cancer, so it follows that the presence of a tumour
confers a prothrombotic state. Indeed, in patients with cancer, each of the three components …

Background Acute promyelocytic leukemia (APL) is associated with a hemorrhagic disorder
of unknown cause that responds to treatment with all-trans-retinoic acid. Methods We …

We designed a multicenter randomized trial comparing chemotherapy with daunorubicin-
Ara C (chemotherapy group) and all transretinoic acid (ATRA) combined to the same …

Acute promyelocytic leukemia (APL) is typified by the t (15; 17), generating the PML-RARα
fusion and predicting a beneficial response to retinoids. However, a sizeable minority of APL …