Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy
R Du, C Huang, K Liu, X Li, Z Dong - Molecular cancer, 2021 - Springer
Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …
EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer
JL Hsu, MC Hung - Cancer and Metastasis Reviews, 2016 - Springer
Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
Understanding resistance to EGFR inhibitors—impact on future treatment strategies
DL Wheeler, EF Dunn, PM Harari - Nature reviews Clinical oncology, 2010 - nature.com
EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis.
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …
Protein localization in disease and therapy
The eukaryotic cell is organized into membrane-covered compartments that are
characterized by specific sets of proteins and biochemically distinct cellular processes. The …
characterized by specific sets of proteins and biochemically distinct cellular processes. The …
Nuclear EGFR as a molecular target in cancer
TM Brand, M Iida, N Luthar, MM Starr… - Radiotherapy and …, 2013 - Elsevier
The epidermal growth factor receptor (EGFR) has been one of the most targeted receptors in
the field of oncology. While anti-EGFR inhibitors have demonstrated clinical success in …
the field of oncology. While anti-EGFR inhibitors have demonstrated clinical success in …
Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab
TM Brand, M Iida, DL Wheeler - Cancer biology & therapy, 2011 - Taylor & Francis
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase belonging to the
HER family of receptor tyrosine kinases. Receptor activation upon ligand binding leads to …
HER family of receptor tyrosine kinases. Receptor activation upon ligand binding leads to …
[HTML][HTML] The nuclear epidermal growth factor receptor signaling network and its role in cancer
TM Brand, M Iida, C Li, DL Wheeler - Discovery medicine, 2011 - ncbi.nlm.nih.gov
The epidermal growth factor receptor (EGFR) is a member of the EGFR family of receptor
tyrosine kinases (RTKs). EGFR activation via ligand binding results in signaling through …
tyrosine kinases (RTKs). EGFR activation via ligand binding results in signaling through …
Nuclear EGFR contributes to acquired resistance to cetuximab
C Li, M Iida, EF Dunn, AJ Ghia, DL Wheeler - Oncogene, 2009 - nature.com
Epidermal growth factor receptor (EGFR) is a ubiquitously expressed receptor tyrosine
kinase involved in the etiology of several human cancers. Cetuximab is an EGFR-blocking …
kinase involved in the etiology of several human cancers. Cetuximab is an EGFR-blocking …
Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations
W Han, HW Lo - Cancer letters, 2012 - Elsevier
The epidermal growth factor receptor (EGFR) pathway is one of the most dysregulated
molecular pathways in human cancers. Despite its well-established importance in tumor …
molecular pathways in human cancers. Despite its well-established importance in tumor …