An aberrant STAT pathway is central to COVID-19

T Matsuyama, SP Kubli, SK Yoshinaga… - Cell Death & …, 2020 - nature.com
COVID-19 is caused by SARS-CoV-2 infection and characterized by diverse clinical
symptoms. Type I interferon (IFN-I) production is impaired and severe cases lead to ARDS …

[HTML][HTML] Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training

CK Roberts, AL Hevener, RJ Barnard - Comprehensive physiology, 2013 - ncbi.nlm.nih.gov
Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

Markers and biomarkers of endothelium: when something is rotten in the state

NV Goncharov, AD Nadeev, RO Jenkins… - Oxidative medicine …, 2017 - Wiley Online Library
Endothelium is a community of endothelial cells (ECs), which line the blood and lymphatic
vessels, thus forming an interface between the tissues and the blood or lympha. This …

Biomarkers for prediction of venous thromboembolism in cancer

I Pabinger, J Thaler, C Ay - Blood, The Journal of the American …, 2013 - ashpublications.org
Cancer patients are at increased risk of deep vein thrombosis and pulmonary embolism. The
incidence among different groups of cancer patients varies considerably depending on …

Cell signaling through protein kinase C oxidation and activation

D Cosentino-Gomes, N Rocco-Machado… - International journal of …, 2012 - mdpi.com
Due to the growing importance of cellular signaling mediated by reactive oxygen species
(ROS), proteins that are reversibly modulated by these reactant molecules are of high …

Human C-reactive protein and the metabolic syndrome

S Devaraj, U Singh, I Jialal - Current opinion in lipidology, 2009 - journals.lww.com
Human C-reactive protein and the metabolic syndrome : Current Opinion in Lipidology Human
C-reactive protein and the metabolic syndrome : Current Opinion in Lipidology Log in or …

The evolving role of C-reactive protein in atherothrombosis

S Devaraj, U Singh, I Jialal - Clinical chemistry, 2009 - academic.oup.com
Background: Inflammation is pivotal in all phases of atherosclerosis. Among the numerous
inflammatory biomarkers, the largest amount of published data supports a role for C-reactive …

The multiple faces of C-reactive protein—physiological and pathophysiological implications in cardiovascular disease

M Boncler, Y Wu, C Watala - Molecules, 2019 - mdpi.com
C-reactive protein (CRP) is an intriguing protein which plays a variety of roles in either
physiological or pathophysiological states. For years it has been regarded merely as a …

Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo

TW Hein, U Singh, J Vasquez-Vivar, S Devaraj, L Kuo… - Atherosclerosis, 2009 - Elsevier
BACKGROUND AND OBJECTIVE: Elevated C-reactive protein (CRP) levels are associated
with increased cardiovascular events and endothelial dysfunction. We have previously …

C-reactive protein polarizes human macrophages to an M1 phenotype and inhibits transformation to the M2 phenotype

S Devaraj, I Jialal - Arteriosclerosis, thrombosis, and vascular …, 2011 - Am Heart Assoc
Objective—Inflammation is pivotal in atherosclerosis. Monocyte-macrophages are crucial in
atherosclerosis. Monocytes can develop into subsets: classically (M1) or alternatively (M2) …