Repeated, intense use of muscles leads to a decline in performance known as muscle
fatigue. Many muscle properties change during fatigue including the action potential …

Intensive activity of muscles causes a decline in performance, known as fatigue, that is
thought to be caused by the effects of metabolic changes on either the contractile machinery …

Complexities in calcium signaling in eukaryotic cells require diversity in the proteins
involved in generating these signals. In this review, we consider the ryanodine receptor …

Malignant hyperthermia (MH) is a disorder of skeletal muscle in which certain anesthetic
agents trigger a sustained elevation in myoplasmic Ca2+ concentration that activates …

A decline of isometric force production is one characteristic of skeletal muscle fatigue. In
fatigue produced by repeated short tetani, this force decline can be divided into two …

The skeletal muscle relaxant dantrolene inhibits the release of Ca 2+ from the sarcoplasmic
reticulum during excitation-contraction coupling and suppresses the uncontrolled Ca 2+ …

This review discusses the mechanism and regulation of Ca release from the cardiac
sarcoplasmic reticulum. Ca is released through the Ca release channel or ryanodine …

In myocardial ischemia, pHi and [ATP] fall, whereas the free [Ca2+] and [Mg2+] rise. The
effects of these changes on cardiac Ca2+ release channel (ryanodine receptor) activity were …

Ca 2+-dependent inhibition of native and isolated ryanodine receptor (RyR) calcium release
channels from sheep heart and rabbit skeletal muscle was investigated using the lipid …

The effects of ionic composition and strength on rabbit skeletal muscle Ca 2+ release
channel (ryanodine receptor) activity were investigated in vesicle-45 Ca 2+ flux, single …